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Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition
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CELL DEATH & DISEASE (2019)
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Necroptosis activation in Alzheimer's disease
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NATURE NEUROSCIENCE (2017)
Parkinson disease
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NATURE REVIEWS DISEASE PRIMERS (2017)
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CELL DEATH AND DIFFERENTIATION (2017)
Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery
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ACS CHEMICAL NEUROSCIENCE (2016)
Regulated necrosis: disease relevance and therapeutic opportunities
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NATURE REVIEWS DRUG DISCOVERY (2016)
Preferential Extracellular Generation of the Active Parkinsonian Toxin MPP+ by Transporter-Independent Export of the Intermediate MPDP+
Stefan Schildknecht et al.
ANTIOXIDANTS & REDOX SIGNALING (2015)
Activation of Necroptosis in Multiple Sclerosis
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CELL REPORTS (2015)
Regulation of tumour necrosis factor signalling: live or let die
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NATURE REVIEWS IMMUNOLOGY (2015)
Characterization of GSK'963: a structurally distinct, potent and selective inhibitor of RIP1 kinase
S. B. Berger et al.
CELL DEATH DISCOVERY (2015)
RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity
Pratyusha Mandal et al.
MOLECULAR CELL (2014)
Disease duration and the integrity of the nigrostriatal system in Parkinson's disease
Jeffrey H. Kordower et al.
BRAIN (2013)
Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models
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CELL DEATH AND DIFFERENTIATION (2013)
Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase
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CELL DEATH AND DIFFERENTIATION (2013)
Unsaturated oxazolones as nonlinear fluorophores
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DYES AND PIGMENTS (2013)
Structural Basis of RIP1 Inhibition by Necrostatins
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STRUCTURE (2013)
Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis
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ACS MEDICINAL CHEMISTRY LETTERS (2013)
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
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CELL (2012)
A novel role for RIP1 kinase in mediating TNFα production
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CELL DEATH & DISEASE (2012)
Programmed Cell Death in Parkinson's Disease
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COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
zVAD-induced necroptosis in L929 cells depends on autocrine production of TNF alpha mediated by the PKC-MAPKs-AP-1 pathway
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CELL DEATH AND DIFFERENTIATION (2011)
The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation
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IMMUNITY (2011)
MPTP Mouse Models of Parkinson's Disease: An Update
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JOURNAL OF PARKINSONS DISEASE (2011)
Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties
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ACS CHEMICAL NEUROSCIENCE (2010)
Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps
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APOPTOSIS (2009)
RIP Kinases at the Crossroads of Cell Death and Survival
Wim Declercq et al.
CELL (2009)
Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
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CELL (2009)
GSTpi Expression in MPTP-Induced Dopaminergic Neurodegeneration of C57BL/6 Mouse Midbrain and Striatum
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JOURNAL OF MOLECULAR NEUROSCIENCE (2009)
TNF-α induces two distinct caspase-8 activation pathways
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CELL (2008)
High throughput microsomal stability assay for insoluble compounds
Li Di et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2006)
Structure-activity relationship study of novel necroptosis inhibitors
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
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NATURE CHEMICAL BIOLOGY (2005)
Attenuation of staurosporine-induced apoptosis, oxidative stress, and mitochondrial dysfunction by synthetic superoxide dismutase and catalase mimetics, in cultured cortical neurons
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EXPERIMENTAL NEUROLOGY (2001)
MPTP activates c-Jun NH2-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo
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JOURNAL OF NEUROCHEMISTRY (2000)