期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/ijms22083948
关键词
caspase-3; radiotracer; activity-based probe; substrate-based probe; positron emission tomography; single-photon emission computed tomography
资金
- University of Antwerp [BOF DOCPRO/FFB180189]
- Research Foundation Flanders (FWO) [12T8821N]
Molecular imaging of apoptosis using activated Caspase-3 as a target provides important methods for diagnosis and monitoring of diseases. Challenges in designing Caspase-3 radiotracers include selectivity, cell permeability, and transient activation. Nuclear imaging, with its high tissue penetration depth and sensitivity, is a good option for detecting small changes in apoptosis levels.
The molecular imaging of apoptosis remains an important method for the diagnosis and monitoring of the progression of certain diseases and the evaluation of the efficacy of anticancer apoptosis-inducing therapies. Among the multiple biomarkers involved in apoptosis, activated caspase-3 is an attractive target, as it is the most abundant of the executioner caspases. Nuclear imaging is a good candidate, as it combines a high depth of tissue penetration and high sensitivity, features necessary to detect small changes in levels of apoptosis. However, designing a caspase-3 radiotracer comes with challenges, such as selectivity, cell permeability and transient caspase-3 activation. In this review, we discuss the different caspase-3 radiotracers for the imaging of apoptosis together with the challenges of the translation of various apoptosis-imaging strategies in clinical trials.
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