期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/ijms22105273
关键词
resveratrol butyrate esters (RBE); maternal; fetal animal model; bisphenol A (BPA); gut microbiota; short-chain fatty acids (SCFAs); offspring
资金
- Ministry of Science and Technology, Republic of China [108-2221-E-992 -046, 109-2221-E-992-051]
- Kaohsiung Chang Gung Memorial Hospital, Taiwan [CORPG8L0301]
- USDA-ARS [SCA 5860667081]
Oral administration of resveratrol butyrate ester has a protective effect against the damage caused by bisphenol A, reducing metabolic disruption and liver inflammation induced by BPA exposure, while also enhancing the barrier formed by intestinal cells.
Resveratrol can affect the physiology or biochemistry of offspring in the maternal-fetal animal model. However, it exhibits low bioavailability in humans and animals. Fifteen-week SD pregnant female rats were orally administered bisphenol A (BPA) and/or resveratrol butyrate ester (RBE), and the male offspring rats (n = 4-8 per group) were evaluated. The results show that RBE treatment (BPA + R30) compared with the BPA group can reduce the damage caused by BPA (p < 0.05). RBE enhanced the expression of selected genes and induced extramedullary hematopoiesis and mononuclear cell infiltration. RBE increased the abundance of S24-7 and Adlercreutzia in the intestines of the male offspring rats, as well as the concentrations of short-chain fatty acids (SCFAs) in the feces. RBE also increased the antioxidant capacity of the liver by inducing Nrf2, promoting the expression of HO-1, SOD, and CAT. It also increased the concentration of intestinal SCFAs, enhancing the barrier formed by intestinal cells, thereby preventing BPA-induced metabolic disruption in the male offspring rats, and reduced liver inflammation. This study identified a potential mechanism underlying the protective effects of RBE against the liver damage caused by BPA exposure during the peri-pregnancy period, and the influence of the gut microbiota on the gut-liver axis in the offspring.
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