4.4 Article

Recognition of food antigens by the mucosal and systemic immune system: Consequences for intestinal development and homeostasis

期刊

出版社

ELSEVIER GMBH
DOI: 10.1016/j.ijmm.2021.151493

关键词

Food antigens; Crohn's disease; Peyer's patches; Apoptosis; Inflammation

资金

  1. Deutsche Forschungsgemeinschaft (DFG) Priority Program SPP1656

向作者/读者索取更多资源

The impact of dietary antigens on the immune system, both microbial and dietary, is crucial for the normal development of mucosal immunity. Research suggests that in a healthy gut, there is a delicate balance between recognition and tolerance of dietary antigens, which is disrupted in patients with Crohn's disease. Understanding this mechanism may provide insights into the potential benefits of dietary intervention therapy.
The impact of nutrition on systemic and intestinal immune responses remains controversially discussed and yet not fully understood. The majority of studies investigating the effects of dietary antigens focused to understand how local and systemic unresponsiveness is induced by innocuous food antigens. Moreover, it has been shown that both, microbial and dietary antigens are essential for the normal development of the mucosal immune system. Based on experimental findings from animals and IBD patients, we propose a model how the intestinal immune system performs the balancing act between recognition and tolerance of dietary antigens at the same time: In the healthy gut, repetitive uptake of dietary antigens by Peyer's patches leads to increasing activation of CD4(+) T cells till hyper-activated lymphocytes undergo apoptosis. In contrast to healthy controls, this mechanism was disturbed in Cmhn's disease patients. This observation might help to better understand beneficial effects of dietary intervention therapy.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据