Genetic diversity and forensic characterization of 15 autosomal microsatellite markers in the North-east Indian Tripuri population

This study was conducted to explore the genomic diversity and forensic characterization of 15 autosomal microsatellite markers in the East Indian Tripuri population. In the studied population, we observed 158 different alleles with the average 10.53 alleles per locus. The locus D2S1338 (PIC= 0.862) was found to be the most polymorphic wheres locus TPOX (PIC= 0.647) as the least polymorphic, among all the studied loci. The locus FGA was found with the highest number of effective alleles (Nall=19) whereas locus TH01 showed least number of effective alleles (Nall=6). The cumulative values for matching probability (CPm), power of discrimination (CPD), power of exclusion CPE), and paternity index (CPI) were found as 1.94x10(-18), 1, 0.999998, and 4.8x10(5) respectively. The studied population showed genetic closeness with the Gorkha population. In neighbor-joining tree, Tripura population pooled with the population of Nepal and Tibet. The genetic data obtained from the present study will not only enrich the existing autosomal STR database but will also be useful for forensic DNA application and genealogical studies.

Automated summary

The study revealed high genetic diversity and polymorphism in the Tripuri population, showing genetic closeness with the Gorkha population. Locus D2S1338 was found to be the most polymorphic, while TPOX was the least polymorphic. The results can enrich the existing STR database, aid forensic DNA application, and genealogical studies.