Gastric protein digestion of goat and cow milk infant formula and human milk under simulated infant conditions

The protein digestion kinetics of goat milk infant formula (GMF) is previously shown to be more comparable to that of human milk (HM) than cow milk infant formula (CMF). To evaluate whether gastric behaviour contributes to differences in protein digestion kinetics, fresh HM, a GMF and a CMF were subjected to in vitro gastric digestion simulating infant conditions. Coagulation behaviour, particle size distribution and viscosity of the digesta were evaluated. After centrifugation of the digesta, total solids and protein distribution, and protein hydrolysis in the cream, serum and pellet fraction were investigated. The GMF and CMF were in general similar with respect to physicochemical and protein breakdown properties. However, a number of notable differences in physicochemical behaviour were observed, which may contribute to faster initial protein digestion of GMF. HM behaved differently from both formulas. These differences provide new insights into the possibilities for improvement of infant formulas.

Automated summary

The protein digestion kinetics of goat milk infant formula is more similar to human milk than cow milk infant formula. The differences in physicochemical behavior observed between the formulas may contribute to faster initial protein digestion of goat milk infant formula. Human milk behaves differently from both formulas, providing new insights into the possibilities for improvement of infant formulas.