4.5 Article

Chronic administration of caffeine alters acesulfame-K intake and features of fungiform taste buds in mice

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出版社

TAYLOR & FRANCIS LTD
DOI: 10.1080/09637486.2021.1905783

关键词

Caffeine; acesulfame-K; fungiform taste bud; taste cell

资金

  1. National Natural Science Foundation of China [31800875, 32072210, 32001831]
  2. Scientific Research Fund of Zhejiang Provincial Education Department [Y201840104]
  3. Foundation of Educational Committee of Zhejiang Province [Y202045188]

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Chronic administration of caffeine in mice led to increased behavioral responses to sweet stimuli, decreased anatomical characteristics of taste buds, and altered expression levels of taste receptor proteins. These changes suggest that chronic caffeine exposure can affect taste sensitivity and behavior.
The objective of this study was to investigate the effects of chronic administration of caffeine on the anatomical characteristics of taste buds, the expression level of taste receptor protein in mice, and preference for a palatable solution. We found that following a 21-day administration of caffeine, mice showed increased behavioural responses to sweet stimuli (acesulfame-K solution). Mirroring this behavioural change, chronic caffeine treatment evidently decreased the maximal cross-sectional area and height of the longitudinal axis of fungiform taste buds, the number of taste cells per fungiform taste bud, and the expression of G protein alpha-gustducin, while the expression of the sweet taste receptors T1R2 and T1R3 was reversed. Our findings demonstrate that chronic administration of caffeine has an impact on taste sensitivity and changes in taste bud features, which may contribute to the alteration of taste behaviour.

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