Electrochemical sensor based on Au@Pt@Au/GO Nanohybrid for acetaminophen determination

In this study, we reported a simple method for the preparing of gold@platinum@gold (Au@Pt@Au) nanoparticles on the surface of graphene oxide (GO) nanosheets. The prepared Au@Pt@Au/GO nanohybrids were characterized by UV-vis spectra, X-ray diffraction (XRD) and Transmission electron microscopy (TEM). The Au@Pt@Au/GO based electrochemical sensor was fabricated by immobilizing the as-prepared Au@Pt@Au/GO nanohybrids onto the bare glassy carbon electrode (GCE). The resulting Au@Pt@Au/GO/GCE electrochemical sensor was proved to detect acetaminophen (ACOP). The results showed that the proposed sensor had a high catalytic activity for ACOP and exhibited good linear relationship in the range of 0.15-125.9 mu M with a detection limit of 0.045 mu M. The proposed method also can be used to detect the pharmaceutical samples.

Automated summary

A simple method for preparing gold@platinum@gold nanoparticles on graphene oxide nanosheets was reported in this study. The resulting electrochemical sensor based on Au@Pt@Au/GO showed high catalytic activity for acetaminophen with good linear relationship and low detection limit. The proposed method can also be used for pharmaceutical sample detection.