4.5 Review

Neurogenic appendicopathy: an underestimated disease-systematic review of the literature

期刊

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
卷 36, 期 9, 页码 1995-2005

出版社

SPRINGER
DOI: 10.1007/s00384-021-03901-1

关键词

Appendicitis; Neurogenic inflammation; Abdominal pain; Appendectomy; Neurogenic appendicopathy

向作者/读者索取更多资源

Neurogenic appendicopathy (NA) is a poorly understood disease often causing recurrent and longer lasting abdominal pain, with an estimated incidence of 10.4% among appendectomies performed in patients with suspected acute appendicitis (AA). The disease is defined by the presence of specific clinical and histopathological criteria, and laparoscopic appendectomy has been shown to be a safe and effective treatment option. Patients with NA may experience years of symptoms before a proper diagnosis is made, highlighting the need for increased awareness and understanding of this condition.
Purpose Appendectomy is one of the most frequently performed surgeries worldwide, but neurogenic appendicopathy (NA) remains a poorly understood disease with controversial clinical management. The aim of this review was to obtain a clear definition of the disease and summarize its management. Methods We performed a systematic review of the literature on NA in PubMed, EMBASE, Web of Science, and Cochrane databases from inception to 19/01/2021 according to PRISMA statement standards. Eligibility criteria were original articles examining histopathology, clinical management, and/or follow-up of patients with NA. The literature review is complemented by a clinical case. Results In 40 articles, the estimated incidence of NA among appendectomies performed in patients with a suspicion of acute appendicitis (AA) was 10.4% (N = 740, range 1.8-32%). NA more frequently causes recurrent and longer lasting pain compared to AA; however, these diseases are usually not clinically or radiologically distinguishable. Based on our analysis, NA is defined as the presence of three criteria: (1) clinical presentation of AA, (2) absence of acute inflammation on histopathology, and (3) presence of S-100-positive spindle cells or proliferation of Schwann cells. Laparoscopic appendectomy has been shown to be a safe and successful treatment. Conclusions NA is a poorly known disease, which may clinically appear as AA but is often related to recurrent and longer lasting abdominal pain. Patients with NA may suffer for years before diagnosis. In cases of typical symptoms, appendectomy should be performed even in cases of macroscopically and radiologically normal-appearing appendices with normal laboratory results.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据