The production, detection, and origin of irisin and its effect on bone cells

Irisin is a muscle factor discovered in 2012 that plays an important role in many tissues, including bone. Eight years since its discovery, there are still many controversies regarding its molecular biology, detection, and effects on bone. This article summarizes the points raised to date, and discusses the mechanisms by which irisin regulates bone cells. The information reviewed here provides a useful foundation for future research. (c) 2021 Elsevier B.V. All rights reserved.

Automated summary

Irisin is a muscle factor discovered in 2012 that plays a crucial role in various tissues, including bone. Despite controversies surrounding its molecular biology, detection, and effects on bone, the information reviewed in this article lays a useful foundation for future research.