期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 175, 期 -, 页码 209-216出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.02.021
关键词
Graphene oxide; Mesoporous silica; Alginate; Core-shell structure; Chemo-photothermal therapy
资金
- Primary Research and Development Plan of Jiangsu Province [BE2019653]
- Natural Science Foundation for Colleges and Universities in Jiangsu Province [20KJA150005]
- Advanced Catalysis and Green Manufacturing Collaborative Innovation Center [ACGM2016-06-27]
A dual stimuli-responsive nanoplatform was designed for controlled drug delivery, featuring high inhibitory rate towards hepatoma cells in cell viability test.
A dual stimuli-responsive nanoplatform was rationally designed for controlled drug delivery. The nanosheets of graphene oxide (GO) were first modified with aminated mesoporous silica (NH2-mSiO(2)), and then methotrexate (MTX) was loaded into the mesopores of mSiO(2). Alginate (Alg) acted as the gatekeeper was then anchored to the MTX-loaded GO/NH2-mSiO(2) by amidation reaction, achieving the encapsulation of MIX in the core-shell structured GO/mSiO(2)@Alg. Due to the high pH sensitivity of amide bond and the excellent photothermal conversion ability of GO, the constructed nanoplatform could be used for pH and near-infrared (NIR) controlled delivery of MTX. The results of cell viability test demonstrate the high inhibitory rate of the dual stimuli-responsive nanoplatform toward hepatoma (HepG2) cells. (C) 2021 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据