Chitosan grafted/cross-linked with biodegradable polymers: A review

Public perception of polymers has been drastically changed with the improved plastic management at the end of their life. However, it is widely recognised the need of developing biodegradable polymers, as an alternative to traditional petrochemical polymers. Chitosan (CH), a biodegradable biopolymer with excellent physiological and structural properties, together with its immunostimulatory and antibacterial activity, is a good candidate to replace other polymers, mainly in biomedical applications. However, CH has also several drawbacks, which can be solved by chemical modifications to improve some of its characteristics such as solubility, biological activity, and mechanical properties. Many chemical modifications have been studied in the last decade to improve the properties of CH. This review focussed on a critical analysis of the state of the art of chemical modifications by cross-linking and graft polymerization, between CH or CH derivatives and other biodegradable polymers (polysaccharides or proteins, obtained from microorganisms, synthetized from biomonomers, or from petrochemical products). Both techniques offer the option of including a wide variety of functional groups into the CH chain. Thus, enhanced and new properties can be obtained in accordance with the requirements for different applications, such as the release of drugs, the improvement of antimicrobial properties of fabrics, the removal of dyes, or as scaffolds to develop bone tissues. (c) 2021 Elsevier B.V. All rights reserved.

Automated summary

The public perception of polymers has changed significantly due to improved plastic management. However, there is a recognized need for developing biodegradable polymers, with chitosan being a potential candidate for replacing traditional petrochemical polymers in biomedical applications. Chemical modifications, such as cross-linking and graft polymerization, have been studied to enhance the properties of chitosan and improve its compatibility with other biodegradable polymers, enabling the creation of new and improved properties for various applications.