4.7 Article

Antifungal activity of double Schiff bases of chitosan derivatives bearing active halogeno-benzenes

期刊

出版社

ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.02.184

关键词

Antifungal activity; Chitosan derivatives; Schiff base

资金

  1. Youth Innovation Promotion Association CAS [2020219]
  2. Natural Science Foundation of Shandong Province of China [ZR2019BD064]
  3. National Key Research and Development Program of China [2019YFD0900705]
  4. Natural Science Foundation of Shandong Province Science and Technology Development Plan [2019GHY112010]

向作者/读者索取更多资源

Chitosan derivatives bearing active halogenated aromatic imines were successfully synthesized with high degrees of substitution, and their antifungal activity was investigated. The results demonstrated that derivatives with higher substitution degrees and halogeno-benzenes exhibited enhanced antifungal effects, providing a practical strategy for developing stronger antifungal agents.
In this study, a series of chitosan derivatives bearing active halogenated aromatic imines were successfully synthesized via Schiff bases with the high degrees of substitution. Detailed structural characterization was carried out using Fourier transform infrared (FTIR) spectroscopy, solid-state C-13 nuclear magnetic resonance (NMR) spectroscopy, and elemental analysis. Besides, the antifungal activity against three common plant pathogenic fungi, including Botrytis cinerea, Fusarium oxysporum f. sp. cucumerinum, and Fusarium oxysporum f. sp. niveum, was investigated using in vitro hyphal measurements. The results showed that double Schiff bases of chitosan derivatives exhibited enhanced antifungal activity compared with chitosan, especially at 1.0 mg/mL. The double Schiff bases of chitosan bearing halogeno-benzenes showed >95% inhibitory indices at 1.0 mg/mL against Botrytis cinereal since halogens had the stronger electron-withdrawing property. The higher degree of substitution was another positive effect to improve the antifungal activity. This study provides a practical strategy to synthesize new double Schiff bases of chitosan derivatives bearing halogeno-benzenes, which could be developed into stronger antifungal agents. (C) 2021 Elsevier B.V. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据