Synthesis of biocompatible chitosan functionalized Ag decorated biocomposite for effective antibacterial and anticancer activity

The transition-metal dichalcogenides (TMDCs) like MoS2 and WS2 are a new and interesting class of materials and show considerable promise for use in a wide variety of fields, including nanomedicine for cancer. The ecofriendly, biodegradability, toxicity, and antimicrobial activity remain an open issue. Herein, we focused on the current demands of two dimensional (2D) TMDCs and produced high-quality, few-layered MoS2 nanosheets. Noble metal Ag incorporated into the 2D-CS/MoS2 NC by the liquid exfoliated process. The manufactured CS/MoS2/Ag hybrid NC showed excellent antibacterial activity against two microorganisms such as Gram-positive (21, 27, and 33 mm) and Gram-negative bacteria (23, 30, and 39 mm). The CS/MoS2/Ag hybrid NC was designed to have significant antibacterial activity against E. coli bacteria than S. aureus. Furthermore, the hybrid NC has a 74.18% cell inhibition against MCF-7 cancer cells. According to the literature relevant, it is the first extensive experimental analysis on the nano-bio interaction of 2D TMDCs nanomaterials in MCF-7 breast cancer cells. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

This study focuses on the application of transition-metal dichalcogenides, preparing high-quality MoS2 nanosheets through liquid exfoliation and incorporating silver to create a nanocomposite with significant antibacterial activity. The experimental results show that this nanocomposite exhibits better antibacterial activity against both Gram-positive and Gram-negative bacteria than Staphylococcus aureus. Additionally, the material has a high cell inhibition rate against MCF-7 breast cancer cells.