期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 134, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2021.105963
关键词
Bacteria; Probiotic; Colon; Lipopolysaccharide; Microvesicle
资金
- Endeavour Research Programme grant entitled Smarter Lives: New opportunities for dairy products across the lifespan from the Ministry of Business, Innovation & Employment, New Zealand [C10X1706]
- New Zealand Ministry of Business, Innovation & Employment (MBIE) [C10X1706] Funding Source: New Zealand Ministry of Business, Innovation & Employment (MBIE)
Sensory nerve endings in the gastrointestinal tract respond to bacterial signaling, affecting intestinal motility and microbial homeostasis through various receptors. Recent studies suggest that bacterial-derived microvesicles can impact gut motility, indicating a potential intercellular communication pathway between the GI tract and the enteric nervous system.
Sensory nerve endings within the wall of the gastrointestinal (GI) tract may respond to bacterial signalling, providing the basis for key biological processes that underlie intestinal motility and microbial homeostasis. Enteric neurons and smooth muscle cells are well known to express an array of receptors, including G-protein coupled receptors and ligand-gated ion channels, that can sense chemical ligands and other bacterially-derived substances. These include short chain fatty acids, secondary bile acids and lipopolysaccharide. For neural detection of microbial activators to occur, luminal substances must first interact with enterocytes for direct signalling or cross paracellularly. Recent studies indicate that bacterial-derived microvesicles can cross the gut epithelial barrier and affect motility. This suggests a possible intercellular communication pathway between the GI tract and the ENS. We explore the idea that bacterial microvesicles can behave as a delivery package for communication between microbe and host.
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