期刊
INTERNAL AND EMERGENCY MEDICINE
卷 16, 期 8, 页码 2181-2191出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s11739-021-02734-8
关键词
Convalescent plasma; COVID-19; Cytokine storm
资金
- Ahvaz Jundishapur University of Medical Sciences
The study found that convalescent plasma has a significant impact on cytokine storm indices in severe COVID-19 patients, increasing levels of lymphocytes and IL-10 while decreasing levels of IL-6, TNF-alpha, and IFN-gamma. However, it did not have a significant effect on reducing mortality rates.
Evaluating the effect of convalescent plasma (CP) on some cytokine storm indices in severe COVID-19 patients. Totally, 62 patients were randomly assigned into two groups for this clinical trial. Patients in the intervention group received one unit (500 mL) plasma on the admission day plus standard drugs while the controls merely received standard treatments. Eventually, primary and secondary outcomes were evaluated. In the CP group, compared with controls, the mean levels of lymphocytes and IL-10 significantly increased while the levels of IL-6, TNF-alpha, and IFN-gamma decreased (p < 0.05). The length of in-hospital stay, and mortality rate did not significantly reduce in the CP group compared with controls (p > 0.05) while WHO severity scores remarkably improved (p = 0.01), despite the higher frequency of underlying diseases among the CP group (66.7%) vs. controls (33.3%). Although CP has a remarkable immunomodulatory and antiviral potential to improve the cytokine storm and disease severity in COVID-19 patients, it did not considerably affect the mortality rate.
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