4.5 Article

Exploration of head-to-tail and head-to-head isomers of a guanine quadruplex platinum-based binder

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Article Chemistry, Multidisciplinary

Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution- and Solid-State Investigations.

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Summary: The study presents a novel planar platinum(II) complex that shows significant binding affinity for guanine quadruplex structures, with good selectivity over duplex structures. Crystal structure analysis confirms double end-capping and dimerization at the 5' interface of the ligand complexed with a telomeric quadruplex.

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