4.7 Article

Synthesis of NNN Chiral Ruthenium Complexes and Their Cytotoxicity Studies

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INORGANIC CHEMISTRY
卷 60, 期 10, 页码 7422-7432

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AMER CHEMICAL SOC
DOI: 10.1021/acs.inorgchem.1c00698

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  1. Science and Engineering Research Board (SERB), Department of Science and Technology (DST), New Delhi
  2. Scheme for Transformational and Advanced Research in Sciences (STARS), Ministry of Human Resource Development (MHRD), Indian Institute of Science (IISc), Bangalore, Department of Bio-Technology (DBT), New Delhi

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The synthesis and characterization of chiral pincer-ruthenium complexes of ((NNN)-N-R2)RuCl2 (PPh3) (R = 3-methylbutyl and 3,3dimethylbutyl) were reported. Cytotoxicity studies showed these complexes inhibited normal and cancer cell growth in a dose-dependent manner. Various assays revealed that the treatment with pincer-ruthenium complexes induced a redox imbalance in cells by upregulating ROS generation and causing necrotic cell death.
The synthesis and characterization of chiral pincer-ruthenium complexes of the type ((NNN)-N-R2)RuCl2 (PPh3) (R = 3-methylbutyl and 3,3dimethylbutyl) is reported here. The cytotoxicity studies of these complexes were studied and compared with the corresponding activity of achiral complexes. The cytotoxic effect of pincer-ruthenium complexes on human dermal fibroblasts and human tongue carcinoma cells assessed using 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay displayed an inhibition of normal and cancer cell growth in a dose-dependent manner. Intracellular reactive oxygen species (ROS) level measurement, lactate dehydrogenase assay, DNA fragmentation, and necrosis studies revealed that treatment with pincer-ruthenium complexes induced a redox imbalance in SAS cells by upregulating ROS generation and caused necrotic cell death by disrupting the cellular membrane integrity.

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