期刊
INORGANIC CHEMISTRY
卷 60, 期 10, 页码 7422-7432出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.inorgchem.1c00698
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资金
- Science and Engineering Research Board (SERB), Department of Science and Technology (DST), New Delhi
- Scheme for Transformational and Advanced Research in Sciences (STARS), Ministry of Human Resource Development (MHRD), Indian Institute of Science (IISc), Bangalore, Department of Bio-Technology (DBT), New Delhi
The synthesis and characterization of chiral pincer-ruthenium complexes of ((NNN)-N-R2)RuCl2 (PPh3) (R = 3-methylbutyl and 3,3dimethylbutyl) were reported. Cytotoxicity studies showed these complexes inhibited normal and cancer cell growth in a dose-dependent manner. Various assays revealed that the treatment with pincer-ruthenium complexes induced a redox imbalance in cells by upregulating ROS generation and causing necrotic cell death.
The synthesis and characterization of chiral pincer-ruthenium complexes of the type ((NNN)-N-R2)RuCl2 (PPh3) (R = 3-methylbutyl and 3,3dimethylbutyl) is reported here. The cytotoxicity studies of these complexes were studied and compared with the corresponding activity of achiral complexes. The cytotoxic effect of pincer-ruthenium complexes on human dermal fibroblasts and human tongue carcinoma cells assessed using 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay displayed an inhibition of normal and cancer cell growth in a dose-dependent manner. Intracellular reactive oxygen species (ROS) level measurement, lactate dehydrogenase assay, DNA fragmentation, and necrosis studies revealed that treatment with pincer-ruthenium complexes induced a redox imbalance in SAS cells by upregulating ROS generation and caused necrotic cell death by disrupting the cellular membrane integrity.
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