期刊
INFLAMMATION
卷 44, 期 5, 页码 1793-1802出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-021-01456-5
关键词
9; 10-Anhydrodehydroartemisinin; artemisinin; multiple sclerosis; Th1; Th17; experimental autoimmune encephalomyelitis
资金
- National Natural Science Foundation of China [32070768, 31871404, 31900658]
- Special Foundation of Chinese Academy of Sciences for strategic pilot technology [XDA12040327]
- Shanghai Municipal Science and Technology Major Project [2017SHZDZX01]
- State Key Laboratory of Drug Research
MS, a demyelinating disease of CNS, currently has no cure. Research shows that ADART can reduce inflammation in EAE, potentially offering a new avenue for treating MS.
Human inflammatory disease, multiple sclerosis (MS), is a demyelinating disease of central nervous system (CNS). The experimental autoimmune encephalomyelitis (EAE) is the most commonly used as experimental model because of its key pathological features' approximation of MS. The interaction between complex elements in immune system and in the CNS determines the MS pathogenesis. However, there is no cure for MS and the treatment for MS still encounters great challenges. Thus, finding a more effective disease-modifying treatment is imminent. In the present study, we investigated whether 9,10-Anhydrodehydroartemisin (ADART), a compound derived from artemisinin, could decrease demyelination in EAE and the underlying mechanisms. In established EAE mice, 100 mg/kg 9,10-Anhydrodehydroartemisinin (ADART) effectively reduced CNS and peripheral immune system infiltration inflammatory cells including CD4(+) IFN-gamma(+) Th1 cells and CD4(+) IL-17A(+) Th17 cells. Correspondingly, the serum level of IFN-gamma and IL-17A was also reduced. In vitro, ADART almost completely inhibited Th17 differentiation, and partially inhibited Th1 differentiation in 10 mu M. This research revealed that ADART could be a great promising avenue among current therapies for MS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据