Clinical Manifestations and Outcome of Scrub Typhus in Infants From Odisha

Objective To study manifestations and outcome of scrub typhus in infants. Methods Case record analysis of infants with scrub typhus admitted to a tertiary care hospital, diagnosed by IgM ELISA from January 1, 2016 to December 31, 2019. Results Out of 374 children diagnosed with scrub typhus, 34 (9%) were infants. Chief presentation were fever 34 (100 %), feeding difficulty 24 (70.6%), lethargy 18 (52.9%) and irritability 15 (44.1%). Clinically, pallor 30 (88.2%), tachycardia 29 (85.3%), tachypnea 24 (70.6%), hepatosplenomegaly 30 (88.2%) and eschar 6 (17.6%) were detected. Significant laboratory parameters were anemia 33 (97.1%), leukocytosis 33 (97.1%), thrombocytopenia 17 (50%) and transaminitis 21 (63.6%). Pneumonia 18 (52.9%) was noticed as the major complication. Infants requiring intensive care 17(50%) had characteristic thrombocytopenia, hypoalbuminemia and transaminitis (P<0.05). They recovered well with doxycycline. Conclusion Manifestation of scrub typhus in infants tends to be severe with combination of hematologic, pulmonary and hepatic involvement requiring intensive care. The response to doxycycline is good.

Automated summary

This study found that manifestations of scrub typhus in infants tend to be severe, involving hematologic, pulmonary, and hepatic issues, often requiring intensive care. Infants requiring intensive care typically exhibit characteristics such as thrombocytopenia, hypoalbuminemia, and elevated transaminases. The response to doxycycline treatment is good in these cases.