4.8 Article

A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance

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Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells

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Summary: The transcription factor Foxp3 plays crucial roles in Treg cell development and function by controlling Foxp3 transcription. Deletion of CNS0 and CNS3 completely abrogates Treg cell generation and impairs Foxp3 expression stability in residual Treg cells, leading to lethal systemic autoimmunity and inflammation. Hierarchical and coordinated activation of Foxp3 CNS0 and CNS3 initiates and stabilizes Foxp3 gene expression, crucially controlling Treg cell development and self-tolerance.

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