4.8 Article

Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

Els Wauters et al.

Summary: Single-cell deep-immune profiling revealed that specific T cells in mild COVID-19 patients exhibit active expansion and function, while in critical COVID-19 they remain more naive. Furthermore, the monocyte-to-macrophage trajectories show enrichment of chronic hyperinflammatory monocytes and depletion of anti-inflammatory alveolar macrophages in critical COVID-19.

CELL RESEARCH (2021)

Review Immunology

The Ugly Duckling Turned to Swan: A Change in Perception of Bystander-Activated Memory CD8 T Cells

Nicholas J. Maurice et al.

Summary: This review discusses the scenarios triggering CD8 T-mem bystander activation and the possible consequences, including manifestations in acute and chronic infections, as well as effects within tumors and following vaccination. The article emphasizes the impact of T cell bystander activation on the host and immune responses, highlighting when it may be beneficial or harmful, and discusses current gaps in knowledge regarding regulatory signals controlling bystander activation.

JOURNAL OF IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Genetic mechanisms of critical illness in COVID-19

Erola Pairo-Castineira et al.

Summary: In critically ill patients with COVID-19, host genetic variants associated with antiviral defense mechanisms and inflammatory organ damage were identified through a genome-wide association study. These genetic signals provide potential targets for therapeutic development and repurposing of existing drugs. Large-scale randomized clinical trials will be essential to confirm the effectiveness of targeted treatment strategies.

NATURE (2021)

Article Medicine, General & Internal

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China

Dawei Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Biochemistry & Molecular Biology

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Mingfeng Liao et al.

NATURE MEDICINE (2020)

Letter Critical Care Medicine

SARS-CoV-2 viral load predicts COVID-19 mortality

Elisabet Pujadas et al.

LANCET RESPIRATORY MEDICINE (2020)

Article Immunology

Comprehensive mapping of immune perturbations associated with severe COVID-19

Leticia Kuri-Cervantes et al.

SCIENCE IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Longitudinal analyses reveal immunological misfiring in severe COVID-19

Carolina Lucas et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

A thermostable, closed SARS-CoV-2 spike protein trimer

Xiaoli Xiong et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

Article Immunology

Methods of Inactivation of SARS-CoV-2 for Downstream Biological Assays

Edward Patterson et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

Article Biochemistry & Molecular Biology

An inflammatory cytokine signature predicts COVID-19 severity and survival

Diane Marie Del Valle et al.

NATURE MEDICINE (2020)

Article Biochemistry & Molecular Biology

A dynamic COVID-19 immune signature includes associations with poor prognosis

Adam G. Laing et al.

NATURE MEDICINE (2020)

Article Multidisciplinary Sciences

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

Prabhu S. Arunachalam et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Neuropilin-1 is a host factor for SARS-CoV-2 infection

James L. Daly et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Qian Zhang et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19

Guillaume Carissimo et al.

NATURE COMMUNICATIONS (2020)

Article Immunology

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

Elizabeth R. Mann et al.

SCIENCE IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19

Yapeng Su et al.

Article Immunology

T cell responses in patients with COVID-19

Zeyu Chen et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human

Marion Espeli et al.

NATURE COMMUNICATIONS (2019)

Article Biotechnology & Applied Microbiology

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

Daehwan Kim et al.

NATURE BIOTECHNOLOGY (2019)

Article Multidisciplinary Sciences

CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells

Nicholas J. Maurice et al.

NATURE COMMUNICATIONS (2019)

Review Cell Biology

MAIT cells and viruses

James E. Ussher et al.

IMMUNOLOGY AND CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

Paracrine costimulation of IFN-γ signaling by integrins modulates CD8 T cell differentiation

Matthew F. Krummel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Immunology

The spectrum of T cell metabolism in health and disease

Glenn R. Bantug et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Cocapture of cognate and bystander antigens can activate autoreactive B cells

Nicholas S. R. Sanderson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Biochemical Research Methods

mixOmics: An R package for 'omics feature selection and multiple data integration

Florian Rohart et al.

PLOS COMPUTATIONAL BIOLOGY (2017)

Review Immunology

Mitochondria are the powerhouses of immunity

Evanna L. Mills et al.

NATURE IMMUNOLOGY (2017)

Review Microbiology

The Human Immune Response to Respiratory Syncytial Virus Infection

Clark D. Russell et al.

CLINICAL MICROBIOLOGY REVIEWS (2017)

Article Biochemical Research Methods

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

Zuguang Gu et al.

BIOINFORMATICS (2016)

Review Immunology

Five layers of receptor signaling in γδ T-cell differentiation and activation

SergioT. Ribeiro et al.

FRONTIERS IN IMMUNOLOGY (2015)

Article Biochemistry & Molecular Biology

The Molecular Signatures Database Hallmark Gene Set Collection

Arthur Liberzon et al.

CELL SYSTEMS (2015)

Article Immunology

Antigen-Dependent versus -Independent Activation of Invariant NKT Cells during Infection

Keli L. Holzapfel et al.

JOURNAL OF IMMUNOLOGY (2014)

Article Biotechnology & Applied Microbiology

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

Charity W. Law et al.

GENOME BIOLOGY (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Biochemical Research Methods

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

Edward Y. Chen et al.

BMC BIOINFORMATICS (2013)

Review Immunology

Beyond oxidative stress: an immunologist's guide to reactive oxygen species

Carl Nathan et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Article Biochemical Research Methods

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

Mark D. Robinson et al.

BIOINFORMATICS (2010)

Article Medicine, Research & Experimental

Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease

Michael T. Borchers et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Review Surgery

The aging of the immune system

Daniela Weiskopf et al.

TRANSPLANT INTERNATIONAL (2009)

Article Biochemical Research Methods

WGCNA: an R package for weighted correlation network analysis

Peter Langfelder et al.

BMC BIOINFORMATICS (2008)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rhe'umatoid arthritis

V Groh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)