A KU'' new sensor for cytosolic DNA in T cells

Adaptive immune cells are usually not equipped with pattern recognition receptors. In this issue of Immunity, Wang et al. revealed an innate-like'' cytosolic DNA-sensing mechanism by the KU complex in aged CD4(+) T cells, which exacerbates aging-related autoimmunity.

Automated summary

A recent study identified an innate-like cytosolic DNA-sensing mechanism in aged CD4(+) T cells, driven by the KU complex, which exacerbates aging-related autoimmunity.