This study highlights the importance of microbiome-induced interferon signaling through gut-derived natural killer cells in minimizing inflammatory responses in the brain and spinal cord. The researchers showed that interferon signaling induces LAMP1(+)TRAIL(+) astrocytes, leading to the death of inflammatory T cells and mitigating degeneration in a mouse model of demyealination.
Microbiome-induced interferon signaling through gut-derived natural killer cells is integral to minimize peripheral inflammatory responses in the brain and spinal cord. In a recent issue of Nature, Sanmarco, Wheeler, et al. define how interferon signaling induces LAMP1(+)TRAIL(+) astrocytes, which cause death of inflammatory T cells, mitigating degeneration in a mouse model of demyealination.
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