期刊
EUROPEAN HEART JOURNAL
卷 37, 期 14, 页码 1113-U105出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehv718
关键词
Athero-thrombosis; Haematopoiesis; Atherosclerosis; Monocytes; Neutrophils; Platelets
资金
- Australian National Health and Medical Research Council (NHMRC)
- National Heart Foundation
- NIH [HL107653]
- Leducq Foundation
Atherosclerosis, the major underlying cause of cardiovascular disease, is characterized by a lipid-driven infiltration of inflammatory cells in large and medium arteries. Increased production and activation of monocytes, neutrophils, and platelets, driven by hypercholesterolaemia and defective high-density lipoproteins-mediated cholesterol efflux, tissue necrosis and cytokine production after myocardial infarction, or metabolic abnormalities associated with diabetes, contribute to atherogenesis and athero-thrombosis. This suggests that in addition to traditional approaches of low-density lipoproteins lowering and anti-platelet drugs, therapies directed at abnormal haematopoiesis, including anti-inflammatory agents, drugs that suppress myelopoiesis, and excessive platelet production, rHDL infusions and anti-obesity and anti-diabetic agents, may help to prevent athero-thrombosis.
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