4.7 Article

Comparison of multiple tractography methods for reconstruction of the retinogeniculate visual pathway using diffusion MRI

期刊

HUMAN BRAIN MAPPING
卷 42, 期 12, 页码 3887-3904

出版社

WILEY
DOI: 10.1002/hbm.25472

关键词

cranial nerve; diffusion magnetic resonance imaging; human Connectome project; retinogeniculate visual pathway; tractography

资金

  1. National Natural Science Foundation of China [61903336, 61976190]
  2. Chinese Postdoctoral Science Foundation [2019M663271]
  3. Key Research & Development Project of Zhejiang Province grant [2020C03070]
  4. National Institutes of Health (NIH) [HHSN26100071, HHSN261200800001E, P41 EB015898, P41 EB015902, P41 EB028741, R01 CA235589, R01 MH074794, R01 MH111917, R01 MH119222, U01 CA199459]
  5. China Scholarship Council

向作者/读者索取更多资源

This study compared four tractography methods and found that UKF-2T and iFOD1 produce the best results for RGVP reconstruction. The iFOD1 method can more accurately estimate the percentage of decussating fibers, while the UKF-2T method produces reconstructed RGVPs that better correspond to known anatomy.
The retinogeniculate visual pathway (RGVP) conveys visual information from the retina to the lateral geniculate nucleus. The RGVP has four subdivisions, including two decussating and two nondecussating pathways that cannot be identified on conventional structural magnetic resonance imaging (MRI). Diffusion MRI tractography has the potential to trace these subdivisions and is increasingly used to study the RGVP. However, it is not yet known which fiber tracking strategy is most suitable for RGVP reconstruction. In this study, four tractography methods are compared, including constrained spherical deconvolution (CSD) based probabilistic (iFOD1) and deterministic (SD-Stream) methods, and multi-fiber (UKF-2T) and single-fiber (UKF-1T) unscented Kalman filter (UKF) methods. Experiments use diffusion MRI data from 57 subjects in the Human Connectome Project. The RGVP is identified using regions of interest created by two clinical experts. Quantitative anatomical measurements and expert anatomical judgment are used to assess the advantages and limitations of the four tractography methods. Overall, we conclude that UKF-2T and iFOD1 produce the best RGVP reconstruction results. The iFOD1 method can better quantitatively estimate the percentage of decussating fibers, while the UKF-2T method produces reconstructed RGVPs that are judged to better correspond to the known anatomy and have the highest spatial overlap across subjects. Overall, we find that it is challenging for current tractography methods to both accurately track RGVP fibers that correspond to known anatomy and produce an approximately correct percentage of decussating fibers. We suggest that future algorithm development for RGVP tractography should take consideration of both of these two points.

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