4.7 Article

Longitudinal changes in regional cerebral blood flow in late middle-aged and older adults with treated and untreated obstructive sleep apnea

期刊

HUMAN BRAIN MAPPING
卷 42, 期 11, 页码 3429-3439

出版社

WILEY
DOI: 10.1002/hbm.25443

关键词

aging; continuous positive airway pressure; neuroimaging; obstructive sleep apnea; regional cerebral blood flow

资金

  1. Canadian Institutes of Health Research [FDN154291, MOP123294]
  2. Fonds de Recherche du Quebec - Sante
  3. Fonds de Recherche du Quebec - Sciences naturelles et genie

向作者/读者索取更多资源

Untreated OSA patients showed decreasing relative rCBF in the left hippocampus and the right parahippocampal gyrus over time, while treated patients exhibited an increasing trend. No changes were observed in the control group over time.
Obstructive sleep apnea (OSA) is associated with abnormal cerebral perfusion at wakefulness, but whether these anomalies evolve over time is unknown. Here, we examined longitudinal changes in regional cerebral blood flow (rCBF) distribution in late middle-aged and older adults with treated or untreated OSA. Twelve controls (64.8 +/- 8.0 years) and 23 participants with newly diagnosed OSA (67.8 +/- 6.2 years) were evaluated with polysomnography and cerebral Tc-99m-HMPAO single-photon emission computed tomography during wakeful rest. OSA participants were referred to a sleep apnea clinic and 13 of them decided to start continuous positive airway pressure (CPAP). Participants were tested again after 18 months. Voxel-based analysis and extracted relative rCBF values were used to assess longitudinal changes. Untreated OSA participants showed decreased relative rCBF in the left hippocampus and the right parahippocampal gyrus over time, while treated participants showed trends for increased relative rCBF in the left hippocampus and the right parahippocampal gyrus. No changes were found over time in controls. Untreated OSA is associated with worsening relative rCBF in specific brain areas over time, while treated OSA shows the opposite. Considering that OSA possibly accelerates cognitive decline in older adults, CPAP treatment could help reduce risk for cognitive impairment.

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