期刊
HISTOPATHOLOGY
卷 79, 期 4, 页码 661-666出版社
WILEY
DOI: 10.1111/his.14416
关键词
DICER1; follicular thyroid carcinoma; histology; macrofollicular variant; mutation
资金
- Swedish Cancer Society
In this study, five cases of follicular thyroid tumors with a macrofollicular architecture were examined, predominantly found in younger female patients and strongly associated with somatic DICER1 gene mutations. The tumors displayed specific histological features such as a broad tumorous capsule, focal infarctions, and areas with papillae, providing clues for further genetic analyses. All cases showed DICER1 gene mutations, indicating a potential link between macrofollicular variants of follicular thyroid tumors and this genetic aberrancy.
Aims DICER1 germline mutations cause DICER1 syndrome, in which multinodular goitre is a common feature. Recently, somatic DICER1 mutations have been reported in sporadic thyroid carcinomas, of which the newly described macrofollicular variant of follicular thyroid carcinoma (MV-FTC) seems particularly enriched for this aberrancy. We report here histological and genetic findings in five follicular thyroid tumours with macrofollicular architecture (four carcinomas and one adenoma). Methods and results We have diagnosed five cases during a year-long period at the Karolinska University Hospital, a tertiary thyroid cancer center with a catchment area of approximately 2.3 million inhabitants. Tumour DNA was interrogated using a commercially available massive parallel sequencing platform. All cases were female patients, ranging from 13 to 33 years at surgery. A single patient was a DICER1 syndrome carrier; the others were sporadic cases. All tumours displayed a macrofollicular architecture with a broad capsule. The MV-FTCs displayed capsular invasion, but never vascular invasion. Areas with degenerative changes (microinfarctions) were noted in all cases, and focal papillary growth was observed in the majority. The Ki-67 proliferation index was always above 4%. All cases displayed DICER1 gene mutations, of which four of five cases displayed RNase IIIb hot-spot missense mutations adjoined by a second, deleterious variant in three of five tumouurs. Conclusions Macrofollicular variants of follicular thyroid tumours are predominantly found in younger females and are strongly linked to somatic DICER1 gene mutations. Histological features such as a broad tumorous capsule, focal infarctions and areas with papillae could constitute clues prompting further genetic analyses.
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