4.5 Article

Effectiveness and safety of oral anticoagulants in elderly patients with atrial fibrillation

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Safety and efficacy of non-vitamin K antagonist oral anticoagulants in elderly patients with atrial fibrillation: systematic review and meta-analysis of 22 studies and 440 281 patients

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Summary: In elderly patients with atrial fibrillation, NOACs are associated with a lower risk of stroke, intracranial bleeding, hemorrhagic stroke, and fatal bleeding compared to VKAs, but increase the risk of gastrointestinal bleedings. The safety profiles of individual NOAC agents vary significantly.

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