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注意:仅列出部分参考文献,下载原文获取全部文献信息。Current progress and future direction in the treatment for hemophilia
Midori Shima
INTERNATIONAL JOURNAL OF HEMATOLOGY (2020)
Marstacimab, a tissue factor pathway inhibitor neutralizing antibody, improves coagulation parameters of ex vivo dosed haemophilic blood and plasmas
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HAEMOPHILIA (2019)
Subcutaneous concizumab prophylaxis in hemophilia A and hemophilia A/B with inhibitors: phase 2 trial results
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BLOOD (2019)
Concizumab restores thrombin generation potential in patients with haemophilia: Pharmacokinetic/pharmacodynamic modelling results of concizumab phase 1/1b data
Hermann Eichler et al.
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Translational Pharmacokinetic/Pharmacodynamic Characterization and Target-Mediated Drug Disposition Modeling of an Anti-Tissue Factor Pathway Inhibitor Antibody, PF-06741086
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A first-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of PF-06741086, an anti-tissue factor pathway inhibitor mAb, in healthy volunteers
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A randomized trial of safety, pharmacokinetics and pharmacodynamics of concizumab in people with hemophilia A
H. Eichler et al.
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Concizumab, an anti-tissue factor pathway inhibitor antibody, induces increased thrombin generation in plasma from haemophilia patients and healthy subjects measured by the thrombin generation assay
E. K. Waters et al.
HAEMOPHILIA (2017)
Mechanistic Modeling of the Pharmacodynamic and Pharmacokinetic Relationship of Tissue Factor Pathway Inhibitor-Neutralizing Antibody (BAY 1093884) in Cynomolgus Monkeys
Jian-Ming Gu et al.
AAPS JOURNAL (2017)
Targeting TFPI for hemophilia treatment
Julie A. Peterson et al.
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Failure of corn trypsin inhibitor to affect the thrombin generation assay in plasma from severe hemophiliacs
B. M. Mohammed et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2014)
Comparison of thrombin generation for paired-platelet-rich plasma collected with and without corn trypsin inhibitor from hemophiliacs treated with factor-VIII inhibitor bypassing agents
A. Tripodi et al.
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The Kunitz-3 domain of TFPI-α is required for protein S-dependent enhancement of factor Xa inhibition
Matthew Ndonwi et al.
BLOOD (2010)
Monitoring thrombin generation: Is addition of corn trypsin inhibitor needed?
Henri M. H. Spronk et al.
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Active tissue factor pathway inhibitor is expressed on the surface of coated platelets
Susan A. Maroney et al.
BLOOD (2007)