期刊
GYNECOLOGIC ONCOLOGY
卷 161, 期 3, 页码 693-699出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygyno.2021.03.008
关键词
Ovarian cancer; Senior oncology; Chemotherapy
资金
- Kay Yow Cancer Fund/V Foundation [D2015-001, D2015-014]
- Biostatistics Core at H. Lee Moffitt Cancer Center & Research Institute [5P30 CA076292-22]
The study revealed that older women aged 70 and above with advanced epithelial ovarian cancer tended to receive less specific treatments, had decreased platinum sensitivity, and significantly lower survival rates. Patients who were younger, received intraperitoneal therapy, completed adjuvant chemotherapy, and had platinum sensitivity showed better overall survival.
Objectives. Older women have a worse prognosis with advanced epithelial ovarian cancer (EOC) and comorbidities likely contribute to poor outcomes. We sought to identify comorbid conditions and treatment-related factors in older women. Methods. A retrospective chart review identified 351 patients who underwent cytoreductive surgery (CRS). 100/351 (28.5%) were >_ 70 years old. Demographic and clinicopathologic information was collected. Crude progression-free (PFS) and overall survival (OS) estimates were calculated using Kaplan-Meier method. Cox proportional hazards regression model was used to estimate hazard ratios and adjustments for confounders. Results. Study subjects >_70 years old had significantly: higher Cumulative Illness Rating Scale-Geriatric (CIRSG) score (5.9 vs 4.3; p = 0.0001), less completion of adjuvant chemotherapy (24% vs 15.1%; p = 0.049), less intraperitoneal (IP) therapy (18.2% vs 35.5%; p = 0.002), less clinical trial participation (16% vs 26.3%; p = 0.040), decreased platinum sensitivity (60% vs 73.7%; p = 0.012) and lacked BRCA mutations (0% vs 12%; p = 0.0006). They were less likely to have optimal CRS (75% vs 86.9%; p = 0.007) with same surgical complexity (p = 0.89). Patients >_70 had significantly worse PFS and OS. In a multivariate analysis, better OS was associated with younger age (<70 years old), any IP therapy, completion of adjuvant chemotherapy, and platinum sensitivity. Conclusion. The older cohort had worse CIRS-G scores (5.9 vs 4.3; p = 0.0001), but no strong associations between comorbidities and treatment characteristics, but less optimal CRS rates (75% vs 86.9%; p = 0.007) with similar surgical complexity and less platinum sensitivity. Our results show comorbid conditions in older patients with advanced EOC may have less impact than tumor biology. (c) 2021 Published by Elsevier Inc.
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