期刊
GENES & DEVELOPMENT
卷 35, 期 9-10, 页码 677-691出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.348241.121
关键词
Drosophila; gap junctions; neural development; spontaneous activity; vertebrates versus invertebrates; visual system; wave of neural activity
资金
- National Institutes of Health [R01 EY13012]
- postdoctoral National Research Service Award [5F32EY027682-02]
During the development of the vertebrate nervous systems, genetic programs assemble an immature circuit that is subsequently refined by neuronal activity evoked by external stimuli. Prior to sensory experience, the developing nervous system also triggers correlated network-level neuronal activity, with retinal waves in the developing vertebrate retina being one example. Drosophila is emerging as a model for studying correlated spontaneous activity in the visual system, comparing it with mammals.
During the development of the vertebrate nervous systems, genetic programs assemble an immature circuit that is subsequently refined by neuronal activity evoked by external stimuli. However, prior to sensory experience, the intrinsic property of the developing nervous system also triggers correlated network-level neuronal activity, with retinal waves in the developing vertebrate retina being the best documented example. Spontaneous activity has also been found in the visual system of Drosophila. Here, we compare the spontaneous activity of the developing visual system between mammalian and Drosophila and suggest that Drosophila is an emerging model for mechanistic and functional studies of correlated spontaneous activity.
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