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NATURE GENETICS (2007)
Inactivation of srnad4 accelerates KrasG12D-Mediated pancreatic neoplasia
Kyoko Kojima et al.
CANCER RESEARCH (2007)
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Daniel N. Frank et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Cutting edge:: Trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+ CD25- T cells
Sabine Dominitzki et al.
JOURNAL OF IMMUNOLOGY (2007)
T cell-produced transforming growth factor-β1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation
Ming O. Li et al.
IMMUNITY (2007)
Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice
Zhiwei Yang et al.
JOURNAL OF CELL BIOLOGY (2007)
Inhibition of TGF-β signaling by IL-15:: A new role for IL-15 in the loss of immune homeostasis in celiac disease
Melika Benahmed et al.
GASTROENTEROLOGY (2007)
KrasG12D and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas
Kamel Izeradjene et al.
CANCER CELL (2007)
SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion
Takanori Kitamura et al.
NATURE GENETICS (2007)
Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-β1-mediated suppression of colitis
Monica Boirivant et al.
GASTROENTEROLOGY (2006)
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-β signaling in cooperation with active Kras expression
Hideaki Ijichi et al.
GENES & DEVELOPMENT (2006)
Transforming growth factor β receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation
Nina M. Munoz et al.
CANCER RESEARCH (2006)
Synergistic function of smad4 and PTEN in suppressing forestomach squamous cell carcinoma in the mouse
Yan Teng et al.
CANCER RESEARCH (2006)
Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice
Xiaoling Xu et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
Byung-Gyu Kim et al.
NATURE (2006)
Deletion of exon I of SMAD7 in mice results in altered B cell responses
Ronggui Li et al.
JOURNAL OF IMMUNOLOGY (2006)
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
E Bettelli et al.
NATURE (2006)
IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration
S Brand et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)
Smad4 haploinsufficiency in mouse models for intestinal cancer
P Alberici et al.
ONCOGENE (2006)
In vivo disruption of TGF-β signaling by Smad7 leads to premalignant ductal lesions in the pancreas
CZ Kuang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice
L Maggio-Price et al.
CANCER RESEARCH (2006)
Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation
WJ Ju et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Impaired transforming growth factor beta signalling in Barrett's carcinogenesis due to frequent SMAD4 inactivation
B. A. Onwuegbusi et al.
GUT (2006)
Smad3 deficiency promotes tumorigenesis in the distal colon of Apc(min/+) mice
Nicole M. Sodir et al.
CANCER RESEARCH (2006)
Smad7 induces turnorigenicity by blocking TGF-β-induced growth inhibition and apoptosis
SK Halder et al.
EXPERIMENTAL CELL RESEARCH (2005)
Transforming growth factor-β suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis
Y Tang et al.
CANCER RESEARCH (2005)
Orofacial and gastrointestinal hyperplasia and neoplasia in smad4(+/-) and elf(+/-)/smad4(+/-) mutant mice
RS Redman et al.
JOURNAL OF ORAL PATHOLOGY & MEDICINE (2005)
Expression and localisation of matrix metalloproteinases and their natural inhibitors in fistulae of patients with Crohn's disease
T Kirkegaard et al.
GUT (2004)
Prognostic significance of the expression of Smad4 and Smad7 in human gastric carcinomas
YH Kim et al.
ANNALS OF ONCOLOGY (2004)
Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection
G Monteleone et al.
GASTROENTEROLOGY (2004)
Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers
B Jung et al.
GASTROENTEROLOGY (2004)
TGFBR1*6A and cancer:: A meta-analysis of 12 case-control studies
B Pasche et al.
JOURNAL OF CLINICAL ONCOLOGY (2004)
Enhanced tumor formation in cyclin D1 x transforming growth factor β1 double transgenic mice with characterization by magnetic resonance imaging
NG Deane et al.
CANCER RESEARCH (2004)
TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
NA Bhowmick et al.
SCIENCE (2004)
Latent membrane protein 2A inhibits transforming growth factor-β1-induced apoptosis through the phosphatidylinositol 3-kinase/Akt pathway
M Fukuda et al.
JOURNAL OF VIROLOGY (2004)
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling
XC He et al.
NATURE GENETICS (2004)
Transforming growth factor β receptor type II inactivation promotes the establishment and progression of colon cancer
S Biswas et al.
CANCER RESEARCH (2004)
Loss of cooperative function of transforming growth factor-β signaling proteins, smad3 with embryonic liver fodrin, a β-spectrin, in primary biliary cirrhosis
B Mishra et al.
LIVER INTERNATIONAL (2004)
Resistance to TGF-β-induced apoptosis in regenerating hepatocytes
B Herrera et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2004)
Stromal fibroblasts in cancer initiation and progression
NA Bhowmick et al.
NATURE (2004)
Arkadia amplifies TGF-β superfamily signalling through degradation of Smad7
D Koinuma et al.
EMBO JOURNAL (2003)
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3
WJ Chen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Generation of a floxed allele of Smad5 for Cre-mediated conditional knockout in the mouse
L Umans et al.
GENESIS (2003)
Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease
L Maiuri et al.
LANCET (2003)
Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats
S Dooley et al.
GASTROENTEROLOGY (2003)
Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease
BC McKaig et al.
AMERICAN JOURNAL OF PATHOLOGY (2003)
Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene
P Hohenstein et al.
GENES CHROMOSOMES & CANCER (2003)
Conditional inactivation of the TGF-β type II receptor using Cre:Lox
A Chytil et al.
GENESIS (2002)
Generation of Smad4/Dpc4 conditional knockout mice
X Yang et al.
GENESIS (2002)
Generation of Bmpr/Alk3 conditional knockout mice
Y Mishina et al.
GENESIS (2002)
Cre/LoxP-mediated inactivation of the murine Pten tumor suppressor gene
R Lesche et al.
GENESIS (2002)
Transforming growth factor-beta in T-cell biology
L Gorelik et al.
NATURE REVIEWS IMMUNOLOGY (2002)
Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts
BC McKaig et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
EL Jackson et al.
GENES & DEVELOPMENT (2001)
Effect of transforming growth factor-β1 on the cell growth and Epstein-Barr virus reactivation in EBV-infected epithelial cell lines
M Fukuda et al.
VIROLOGY (2001)
Hepatocellular expression of a dominant-negative mutant TGF-β type II receptor accelerates chemically induced hepatocarcinogenesis
S Kanzler et al.
ONCOGENE (2001)
Genetic regulation of autoimmune disease:: BALB/c background TGF-β1-deficient mice develop necroinflammatory IFN-γ-dependent hepatitis
JD Gorham et al.
JOURNAL OF IMMUNOLOGY (2001)
TGF-β receptor controls B cell responsiveness and induction of IgA in vivo
BB Cazac et al.
IMMUNITY (2000)
Tumor necrosis factor-α inhibits transforming growth factor-β/Smad signaling in human dermal fibroblasts via AP-1 activation
F Verrecchia et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice
XL Xu et al.
ONCOGENE (2000)
Characterization of growth-differentiation factor 15, a transforming growth factor β superfamily member induced following liver injury
EC Hsiao et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Kupffer cell depletion by CI2MDP-liposomes alters hepatic cytokine expression and delays liver regeneration after partial hepatectomy
C Meijer et al.
LIVER (2000)
Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
L Gorelik et al.
IMMUNITY (2000)
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