Epidemiology of extended-spectrum β-lactamase and metallo-β-lactamase-producing Escherichia coli in South Asia

Aim: To determine the prevalence of extended-spectrum beta-lactamase (ESBL) and metallo-beta-lactamase (MBL)-producing Escherichia coli in South Asia. Methodology: A systematic review and meta-analysis of data published in PubMed, EMBASE, Web of Science and Scopus. Results: The pooled prevalence of ESBL and MBL-producing E. coli in South Asia were 33% (95% CI: 27-40%) and 17% (95% CI: 12-24%), respectively. The prevalence of bla(CTX-M) type was 58% (95% CI: 49-66%) with bla(CTX-M-15) being the most prevalent (51%, 95% CI: 40-62%) variant. The most prevalent MBL variant was bla(NDM-1) (33%, 95% CI: 20-50%). Conclusion: This study suggests a high prevalence of ESBLs and MBLs among E. coli clinical isolates. Comprehensive resistance surveillance is required to guide clinicians prescribing antibiotics in South Asia.

Automated summary

The study revealed a high prevalence of ESBLs and MBLs among E. coli clinical isolates in South Asia, with bla(CTX-M-15) and bla(NDM-1) being the most prevalent variants. Comprehensive resistance surveillance is needed in South Asia to guide antibiotic prescribing.