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Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats
D. Lebrecht et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor α gene expression in mouse C2C12 myoblasts localization of the α2 form of AMP-activated protein kinase
Atsushi Suzuki et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Distinct roles of autophagy in the heart during ischemia and reperfusion - Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy
Yutaka Matsui et al.
CIRCULATION RESEARCH (2007)
Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy
Anna A. Noga et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)
NOX5 variants are functionally active in endothelial cells
Rachida S. BelAiba et al.
FREE RADICAL BIOLOGY AND MEDICINE (2007)
Role of oxidative stress in cardiac hypertrophy and remodeling
Eiki Takimoto et al.
HYPERTENSION (2007)
Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overload-induced cardiac hypertrophy
Hong-Liang Li et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle
J. B. Birk et al.
JOURNAL OF PHYSIOLOGY-LONDON (2006)
Role of the α2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia
Elham Zarrinpashneh et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2006)
A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway
Min Xie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
Julie St-Pierre et al.
CELL (2006)
Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro
Milica Momcilovic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
AMPK alterations in cardiac physiology and pathology: enemy or ally?
Jason R. B. Dyck et al.
JOURNAL OF PHYSIOLOGY-LONDON (2006)
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1
K Sakamoto et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2006)
Involvement of the nicotinamide adenosine dinucleotide phosphate oxidase isoform Nox2 in cardiac contractile dysfunction occurring in response to pressure overload
DJ Grieve et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2006)
Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
BJ Davis et al.
DIABETES (2006)
Activation of AMP-activated protein kinase reduces hyperglycemia-Induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells
D Kukidome et al.
DIABETES (2006)
Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells?
AM Evans et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
RJ Shaw et al.
SCIENCE (2005)
NAD(P)H oxidase 4 mediates transforming growth factor-β1-induced differentiation of cardiac fibroblasts into myofibroblasts
I Cucoranu et al.
CIRCULATION RESEARCH (2005)
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events):: a randomised controlled trial
JA Dormandy et al.
LANCET (2005)
Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure
I Shiojima et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells
JD MacLellan et al.
DIABETES (2005)
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
SA Hawley et al.
CELL METABOLISM (2005)
Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the γ2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency
B Burwinkel et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2005)
NAD(P)H oxidases in rat basilar arterial endothelial cells
T Ago et al.
STROKE (2005)
Cyclooxygenase-2 inhibition improves vascular endothelial dysfunction in a rat model of endotoxic shock: Role of inducible nitric-oxide synthase and oxidative stress
A Virdis et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
NO/redox disequilibrium in the failing heart and cardiovascular system
JM Hare et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Vascular NADPH oxidases: molecular mechanisms of activation
RP Brandes et al.
CARDIOVASCULAR RESEARCH (2005)
Thiazolidinediones, like metformin, inhibit respiratory complex I -: A common mechanism contributing to their antidiabetic actions?
B Brunmair et al.
DIABETES (2004)
Nox enzymes and the biology of reactive oxygen
JD Lambeth
NATURE REVIEWS IMMUNOLOGY (2004)
Beneficial and deleterious effects of rosiglitazone on hypertension development in spontaneously hypertensive rats
LY Wu et al.
AMERICAN JOURNAL OF HYPERTENSION (2004)
Stimulators of AMP-activated protein kinase inhibit the respiratory burst in human neutrophils
G Alba et al.
FEBS LETTERS (2004)
Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte
AYM Chan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Adiponectin-mediated modulation of hypertrophic signals in the heart
R Shibata et al.
NATURE MEDICINE (2004)
Possible involvement of the α1 isoform of 5′ AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle
T Toyoda et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2004)
Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload
JR McMullen et al.
CIRCULATION (2004)
The AMP-activated protein kinase cascade - a unifying system for energy control
D Carling
TRENDS IN BIOCHEMICAL SCIENCES (2004)
TSC2 mediates cellular energy response to control cell growth and survival
K Inoki et al.
CELL (2003)
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
A Woods et al.
CURRENT BIOLOGY (2003)
Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2
S Horman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Oxygen free radical release in human failing myocardium is associated with increased activity of Rac1-GTPase and represents a target for statin treatment
C Maack et al.
CIRCULATION (2003)
Effects of chronic AICAR treatment on fiber composition, enzyme activity, UCP3, and PGC-1 in rat muscles
M Suwa et al.
JOURNAL OF APPLIED PHYSIOLOGY (2003)
AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress
D Nagata et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Increased myocardial NADPH oxidase activity in human heart failure
C Heymes et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2003)
A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias
ER Hudson et al.
CURRENT BIOLOGY (2003)
New targets of AMP-activated protein kinase
L Hue et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2003)
Regulation of hypertrophic and apoptotic signaling pathways by reactive oxygen species in cardiac myocytes
A Sabri et al.
ANTIOXIDANTS & REDOX SIGNALING (2003)
Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase
MH Zou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis
S Horman et al.
CURRENT BIOLOGY (2002)
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
SA Hawley et al.
DIABETES (2002)
The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
LGD Fryer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.
DR Bolster et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Diabetes and atherosclerosis - Epidemiology, pathophysiology, and management
JA Beckman et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2002)
Superoxide production and expression of Nox family proteins in human atherosclerosis
D Sorescu et al.
CIRCULATION (2002)
The inflammatory response in myocardial infarction
NG Frangogiannis et al.
CARDIOVASCULAR RESEARCH (2002)
A Ca2+-activated NADPH oxidase in testis, spleen, and lymph nodes
B Bánfi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy
R Tian et al.
CIRCULATION (2001)
The regulation of AMP-activated protein kinase by H2O2.
SL Choi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Novel gp91phox homologues in vascular smooth muscle cells -: Nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways
B Lassègue et al.
CIRCULATION RESEARCH (2001)
A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall
A Görlach et al.
CIRCULATION RESEARCH (2000)
A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle
D Milan et al.
SCIENCE (2000)
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