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DNA damage response and cellular senescence in tissues of aging mice
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AGING CELL (2009)
Role of Hydrogen Peroxide in NF-κB Activation: From Inducer to Modulator
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ANTIOXIDANTS & REDOX SIGNALING (2009)
Characterization of Dasatinib and Its Structural Analogs as CYP3A4 Mechanism-Based Inactivators and the Proposed Bioactivation Pathways
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DRUG METABOLISM AND DISPOSITION (2009)
Inflammation in Atherosclerosis From Pathophysiology to Practice
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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)
Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence
Olga Moiseeva et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
David E. Harrison et al.
NATURE (2009)
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
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NATURE CELL BIOLOGY (2009)
Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity
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NATURE CHEMICAL BIOLOGY (2009)
A crucial role for adipose tissue p53 in the regulation of insulin resistance
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NATURE MEDICINE (2009)
Reactive oxygen intermediate-induced pathomechanisms contribute to immunosenescence, chronic inflammation and autoimmunity
Thorsten Peters et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2009)
Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans
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PLOS GENETICS (2009)
STATs in cancer inflammation and immunity: a leading role for STAT3
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NATURE REVIEWS CANCER (2009)
NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2008)
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CANCER RESEARCH (2008)
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CELL (2008)
Metformin slows down aging and extends life span of female SHR mice
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CELL CYCLE (2008)
Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin
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COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2008)
ROS and p53: A versatile partnership
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FREE RADICAL BIOLOGY AND MEDICINE (2008)
Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
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MOLECULAR CELL (2008)
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MOLECULAR CELL (2008)
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NATURE (2008)
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
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A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcino genic properties
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FOOD AND CHEMICAL TOXICOLOGY (2007)
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ANTIOXIDANTS & REDOX SIGNALING (2007)
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GENOME RESEARCH (2007)
Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts
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CELL DEATH AND DIFFERENTIATION (2007)
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
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PLOS BIOLOGY (2007)
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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
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SCIENCE (2006)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Oxidative stress augments the production of matrix metalloproteinase-1, cyclooxygenase-2, and prostaglandin E2 through enhancement of NF-κB activity in lipopolysaccharide-activated human primary monocytes
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JOURNAL OF IMMUNOLOGY (2005)
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
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NATURE (2005)
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FEBS LETTERS (2005)
Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas
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MOLECULAR AND CELLULAR BIOLOGY (2005)
Understanding the odd science of aging
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CELL (2005)
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MOLECULAR AND CELLULAR BIOLOGY (2005)
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MOLECULAR CELL (2004)
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FREE RADICAL BIOLOGY AND MEDICINE (2004)
Bcl-2 is a key factor for cardiac fibroblast resistance to programmed cell death
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
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NATURE (2004)
Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b
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ONCOGENE (2004)
Proteasome inhibition induces a senescence-like phenotype in primary human fibroblasts cultures
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BIOGERONTOLOGY (2004)
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a
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MOLECULAR CELL (2004)
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
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PHYSIOLOGICAL GENOMICS (2003)
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
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NATURE (2003)
Reversal of human cellular senescence:: roles of the p53 and p16 pathways
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EMBO JOURNAL (2003)
Central role of the proteasome in senescence and survival of human fibroblasts - Induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
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CELL (2003)
Curcurnin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
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BIOCHEMICAL JOURNAL (2003)
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53
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MOLECULAR AND CELLULAR BIOLOGY (2001)
Subcytotoxic H2O2 stress triggers a release of transforming growth factor-β1, which induces biomarkers of cellular senescence of human diploid fibroblasts
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
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