期刊
FOOD HYDROCOLLOIDS
卷 113, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodhyd.2020.106493
关键词
Self-assembly nanoparticles; Zein; Chondroitin sulfate; Sophorolipid; Curcumin
资金
- National Natural Science Foundation of China [31871786]
The study successfully designed curcumin-loaded ternary self-assembly composite nanoparticles consisting of zein, chondroitin sulfate, and sophorolipid, showing high encapsulation efficiency and stability. These nanoparticles not only enhanced the solubility of curcumin but also exhibited good biocompatibility and anticancer activity.
The curcumin (Cur) loaded ternary self-assembly composite nanoparticles consisting of zein, chondroitin sulfate (CS) and sophorolipid (Spl) were designed successfully with zein-to-Spl mass ratio of 1:1 (Cur-Z/CS/SplNPs(1:1)), showing nano-spherical structure with high zeta-potential and encapsulation efficiency. The encapsulation process converted Cur from crystal to amorphous nature, involving electrostatic force, hydrophobic interaction and hydrogen bonding. Spl improved the resistance of zein to degeneration with or without Cur and CS. Cur-Z/CS/ SplNPs(1:1) showed stability at pH > 4.0 and the better thermostability (80 degrees C) at a faster rate. Additionally, Cur showed the best chemical stability in Cur-Z/CS/SplNPs(1:1) under the condition of 4 degrees C in the dark with half-life of 58.74. And Cur-Z/CS/SplNPs(1:1) enhanced the aqueous solubility of Cur about 160 times higher than that of free Cur in powder state. Furthermore, Cur-Z/CS/SplNPs(1:1) exhibited the biocompatibility, bioaccessibility (68.06%) and anticancer activity against HepG2, MCF-7 and HeLa cells. This study provides new insights into the application of Spl in protein/polysaccharide delivery systems in the food, pharmaceutical and cosmetic industries.
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