期刊
FOOD CHEMISTRY
卷 361, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2021.130119
关键词
Lycopene; 8-Carotene; Lutein; Geometrical isomer; Bioavailability; Tissue accumulation
资金
- Adaptable and Seamless Technology transfer Program through Targetdriven R&D (A-STEP) from Japan Science and Technology Agency (JST) [JPMJTR20U7]
- KAKENHI from Japan Society for the Promotion of Science (JSPS) [19 K15779]
The study found that carotenoid Z-isomers have higher bioavailability and tissue accumulation efficiency in rats compared to all-E-isomers, and diets rich in Z-isomers also significantly increased the total Z-isomer ratio in plasma and various tissues. This suggests that carotenoid Z-isomers may bring remarkable health benefits due to their potentially higher antioxidant activity.
This study investigated the differences in bioavailability and tissue accumulation efficiency between all-E- and Zisomer-rich carotenoids after oral administration to rats. Three commercially important carotenoids (lycopene, 8-carotene, and lutein) were chosen for the study. For all carotenoids, feeding with Z-isomer-rich diets increased their concentrations in plasma and tissues at least similar to or more than the all-E-isomer-rich diets, e.g., in rats fed a Z-isomer-rich lycopene, the lycopene concentrations in the plasma and liver after the 2-week administration were respectively 6.2 and 11.6 times higher than those fed an all-E-isomer-rich diet. These results strongly indicate that carotenoid Z-isomers have higher bioavailability and tissue accumulation efficiency than the all-Eisomers. Moreover, diets rich in carotenoid Z-isomers significantly improved the total Z-isomer ratio in plasma and several tissues compared to the all-E-isomers. Since carotenoid Z-isomers potentially have higher antioxidant activity than the all-E-isomers, their accumulation in the body might bring remarkable health benefits.
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