期刊
FLUID PHASE EQUILIBRIA
卷 542, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.fluid.2021.113091
关键词
Chiral ionic liquids; Amino acids; Thermophysical properties; Optical rotation; Ecotoxicity; Aqueous biphasic systems
资金
- Portuguese Foundation for Science and Technology/MCTES [UIDB/50011/2020, UIDP/50011/2020]
- FEDER [POCI-01-0145FEDER-030750 (PTDC/EQUEPQ/30750/2017)]
- national funds (OE), through FCT/MCTES
- FEDER
- FCT through PIDDAC
- FCT [SFRH/BD/143612/2019]
- FCT -Fundacao para a Ciencia e a Tecnologia, I.P. [CEECIND/00831/2017, CEECIND/03076/2018]
- POCI
- PORL
- [022161]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/143612/2019] Funding Source: FCT
Ten chiral ionic liquids (CILs) were synthesized using amino acids as anions and tetrabutylammonium or cholinium as cations. The research evaluated their ecotoxicity, thermophysical properties, and the impact of cations on density and viscosity. Results indicated that cations have a more pronounced impact on the formation of aqueous biphasic systems.
By using amino acids as anions, ten chiral ionic liquids (CILs) composed of tetrabutylammonium or cholinium as cations were synthesized by neutralization reactions and further characterized by assessing their optical rotation, thermophysical properties (melting and decomposition temperatures, density, viscosity and refractive index) and ecotoxicity against the marine bacterium Aliivibrio fischeri. The CILs are shown to display, in general, high thermal stability (> 439 K) and low to moderate toxicities (86217 mg L-1). It was found that the cation plays an important role in the density and viscosity of the CILs. Additionally, the effect of CILs optical configuration on these properties was evaluated by comparing the tetrabutylammonium D/L-phenylalaninate ([N-4444][D/L-Phe]) and cholinium D/L-phenylalaninate ([N-1112((OH))][D/L-Phe]) pairs. Finally, the CILs potential to form aqueous biphasic systems with sodium sulfate, citrate buffer and phosphate buffer was assessed and the ternary phase diagrams were determined. These allowed to infer the impact of the CILs' cation, anion, and salt on the aqueous biphasic system formation. It was shown that the cation has a more pronounced impact on the aqueous biphasic system formation than the anion. Cholinium-based CILs failed to form aqueous biphasic systems with sodium sulfate under the tested conditions, contrary to the more hydrophobic tetrabutylammonium-based CILs. The ability of the tested salt and buffers to induce liquid-liquid demixing shows that citrate buffer and sodium sulfate represent the weakest and the strongest salting-out agents, respectively. (C) 2021 Elsevier B.V. All rights reserved.
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