期刊
FERTILITY AND STERILITY
卷 116, 期 1, 页码 243-254出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2021.02.031
关键词
Adenomyosis; H-1-NMR; metabolomics; serum; MRI
资金
- Merck Biopharma France Research Grant
The study found differences in serum metabolic profiles between patients with adenomyosis and the control group, with specific metabolic profiles observed in different adenomyosis phenotypes. These metabolic changes are associated with processes such as immune activation, cell proliferation, and cell migration.
Objective: To determine whether the adenomyosis phenotype affects the proton nuclear magnetic resonance (H-1-NMR)-based serum metabolic profile of patients. Design: Cohort study. Setting: University hospital-based research center. Patients: Seventy-seven patients who underwent laparoscopy for a benign gynecologic condition. Interventions: Pelvic magnetic resonance imaging and collection of a venous peripheral blood sample were performed during the pre-operative workup. The women were allocated to the adenomyosis group (n = 32), or the control group (n = 45). The adenomyosis group was further subdivided into two groups: diffuse adenomyosis of the inner myometrium (n = 14) and focal adenomyosis of the outer myometrium (n = 18). Other adenomyosis phenotypes were excluded. Main Outcome Measures: Metabolomic profiling based on H-1-NMR spectroscopy in combination with statistical approaches. Results: The serum metabolic profiles of the patients with adenomyosis indicated lower concentrations of 3-hydroxybutyrate, glutamate, and serine compared with controls. Conversely, the concentrations of proline, choline, citrate, 2-hydroxybutyrate, and creatinine were higher in the adenomyosis group. The focal adenomyosis of the outer myometrium and the diffuse adenomyosis phenotypes also each exhibited a specific metabolic profile. Conclusion: Serum metabolic changes were detected in women with features of adenomyosis compared with their disease-free counterparts, and a number of specific metabolic pathways appear to be engaged according to the adenomyosis phenotype. The metabolites with altered levels are particularly involved in immune activation as well as cell proliferation and cell migration. Nevertheless, this study did find evidence of a correlation between metabolite levels and symptoms thought to be related to adenomyosis. Further studies are required to determine the clinical significance of these differences in metabolic profiles. ((C) 2021 by American Society for Reproductive Medicine.)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据