期刊
FEBS LETTERS
卷 595, 期 12, 页码 1734-1747出版社
WILEY
DOI: 10.1002/1873-3468.14100
关键词
DNA methylation; long noncoding RNA; transcribing activation; transcription factor; transposable elements
资金
- National Key Research and Development Program [2016YFD0101006]
- National Natural Science Foundation of China (NSFC) [31971985, 31900395, 32000379]
- China Postdoctoral Science Foundation [2019M652094, 2018M632477]
- Dabeinong Funds for Discipline Development
- Talent Training in Zhejiang University
- Fundamental Research Funds for the Central Universities
- JCIC-MCP project
The study found significant activation of lincRNAs in the absence of CG DNA methylation rather than non-CG. This research provides us with a working model of the contribution of DNA methylation to regulation of the dynamic activity of lincRNA transcription.
The noncoding regions throughout the genome are in large part comprised of transposable elements (TEs), some of which are functionalized with long intergenic noncoding RNAs (lincRNAs). DNA methylation is predominantly associated with TEs, but little is known about its contribution to the transcription of lincRNAs. Here, we examine the lincRNA profiles of DNA methylation-related mutants of five species, Arabidopsis, rice, tomato, maize, and mouse, to elucidate patterns in lincRNA regulation under altered DNA methylation status. Significant activation of lincRNAs was observed in the absence of CG DNA methylation rather than non-CG. Our study establishes a working model of the contribution of DNA methylation to regulation of the dynamic activity of lincRNA transcription.
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