期刊
FEBS JOURNAL
卷 289, 期 5, 页码 1352-1368出版社
WILEY
DOI: 10.1111/febs.16021
关键词
EMT; melanoma; phenotype switching
资金
- FWO [G.0929.16N, 1210520N]
- Stichting tegen kanker, Melanoma Research Alliance (MRA, EIA) [623591]
- KULeuven (C1 grant)
- VIB PhD program, Kom op Tegen Kanker
- Marie Curie Individual Fellowship [841092]
- Alexander von Humboldt Foundation
- Marie Curie Actions (MSCA) [841092] Funding Source: Marie Curie Actions (MSCA)
The review discusses the emergence of a process similar to EMT in melanoma, as well as how comparative analysis with EMT state(s) in epithelial cancers can provide clues for identifying clinically relevant biomarkers for prognosis and new therapeutic strategies.
Epithelial-to-mesenchymal transition (EMT), a process through which epithelial tumor cells acquire mesenchymal phenotypic properties, contributes to both metastatic dissemination and therapy resistance in cancer. Accumulating evidence indicates that nonepithelial tumors, including melanoma, can also gain mesenchymal-like properties that increase their metastatic propensity and decrease their sensitivity to therapy. In this review, we discuss recent findings, illustrating the striking similarities-but also knowledge gaps-between the biology of mesenchymal-like state(s) in melanoma and mesenchymal state(s) from epithelial cancers. Based on this comparative analysis, we suggest hypothesis-driven experimental approaches to further deepen our understanding of the EMT-like process in melanoma and how such investigations may pave the way towards the identification of clinically relevant biomarkers for prognosis and new therapeutic strategies.
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