4.2 Article

DESIGN, SYNTHESIS, CHARACTERIZATION, AND CYTOTOXICITY EVALUATION OF NEW 4-BENZYL-1,3-OXAZOLE DERIVATIVES BEARING 4-(4-CHLOROPHENYLSULFONYL)PHENYL MOIETY

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FARMACIA
卷 69, 期 2, 页码 314-324

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SOC STIINTE FARMACEUTICE ROMANIA
DOI: 10.31925/farmacia.2021.2.17

关键词

N-acyl-alpha-amino acid; 1,3-oxazol-5(4H)-one; 1,3-oxazole; cytotoxicity

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This study presents the design, synthesis, characterization, and cytotoxicity evaluation of eight organic compounds containing the 4-(4-chlorophenylsulfonyl)phenyl moiety. The structures of synthesized compounds were confirmed by elemental analysis and spectral methods, and their purity was determined by RP-HPLC. The cytotoxic effect of the synthesized compounds was evaluated on Daphnia magna crustacean.
This paper presents the design, synthesis, characterization, and cytotoxicity evaluation of eight organic compounds that have in their molecules the 4-(4-chlorophenylsulfonyl)phenyl moiety: four acyclic precursors derived from phenylalanine (one N-acyl-alpha-amino acid, one N-acyl-alpha-amino acyl chloride, and two N-acyl-alpha-amino ketones), and four cyclization products: one 1,3-oxazol-5(4H)-one, and three 1,3-oxazoles substituted in 5-position with phenyl, p-tolyl, and m-xylyl group, respectively. Structures of synthesized compounds were confirmed by elemental analysis and spectral methods (UV-Vis, FT-IR, MS, H-1 and C-13-NMR). The compounds purity determination was performed by RP-HPLC. Cytotoxic effect of synthesized compounds was evaluated on Daphnia magna crustacean.

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