期刊
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
卷 21, 期 5, 页码 455-464出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/14737159.2021.1917384
关键词
Acute kidney disease; lipocalin; prognosis; mortality; renal replacement therapy
类别
资金
- Ministry of Science and Technology, Taiwan [106-2314-B-182A-118-MY3, 109-2314-B-182A-124]
NGAL serves as a widely studied biomarker for acute kidney injury, with the potential to predict disease progression, mortality, and differentiate between AKI etiologies. Urine and plasma NGAL levels can aid in predicting AKI severity, but they have suboptimal performance for predicting renal replacement therapy or successful discontinuation. Factors like sepsis, baseline renal function, sample collection timing, and lack of internationally approved reference material can affect the prediction performance of NGAL.
Introduction: Human lipocalin-2, known as neutrophil gelatinase-associated lipocalin (NGAL), is a widely studied biomarker of acute kidney injury (AKI). Areas covered: NGAL can serve as a predictor of AKI, disease progression, and mortality and can help in differentiating between AKI etiologies. We conducted a systematic review in the PubMed and Medline databases involving the clinical application of NGAL in patients with AKI. Expert opinion: In this review, we explored the usefulness of NGAL for AKI or clinical outcome prediction. The use of urine or blood NGAL levels alone or in combination with a clinical prediction model may facilitate AKI prediction, severity prediction, AKI etiological differentiation, and mortality prediction. For AKI prediction, urine and plasma NGAL levels have an area under the curve (AUC) ranging from 0.71 to 0.90 and from 0.71 to 0.89, respectively, in different populations. The diagnostic performance of NGAL alone for renal replacement therapy or successful discontinuation prediction is suboptimal (AUC range: 0.65-0.81). Sepsis limits the application of NGAL as a clinical predictor, and the prediction performance of NGAL is affected by baseline renal function, timing of sample collection, and underlying comorbidities. The lack of internationally approved reference material also limits the usefulness of NGAL.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据