期刊
EXPERT REVIEW OF MEDICAL DEVICES
卷 18, 期 4, 页码 351-365出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17434440.2021.1904894
关键词
Drug-eluting stents; bioresorbable scaffold; new generation scaffold; peripheral artery disease; gastrointestinal system
资金
- Natural Science Foundation of Zhejiang Province, China [LQ20H180004]
- Science Foundation Ireland [RSF 1413]
This article summarizes the lessons learned from the first generation of bioresorbable scaffolds (BRSs), updates on the improvements and clinical trial results of new generation BRSs, as well as applications of bioresorbable metallic alloys. Research suggests that BRSs technology has wide potential applications in coronary artery disease, but further studies are needed.
Introduction: The first-generation bioresorbable scaffolds (BRSs) had a large strut profile to compensate for the insufficient radial strength of bioresorbable polymer materials, resulting in higher scaffold thrombosis rates than conventional drug-eluting stents. To improve the clinical safety and efficacy, the new generation BRSs have been improved by optimal structure design, post-processing of bioresorbable polymer materials, or altering bioresorbable metallic alloys. Areas covered: This review summarizes the lessons learned from the first-generation BRS, updates the clinical outcomes of trials evaluating ABSORB bioresorbable vascular scaffold at long-term and bioresorbable metallic alloy-based devices, and examines recent outcomes of BRS treated in STEMI patients. This review also provides an overview of the current clinical data of seven BRSs manufactured in Asia, and of the BRSs extended application in other clinical arenas. Expert opinion: Drawbacks of the first-generation BRSs need to be addressed by the next generation of these stents with novel materials and technologies. Clinical research, including randomized controlled trials, are required to further evaluate BRSs application in coronary artery disease. The encouraging results of BRSs innovation applied in the peripheral arteries and gastrointestinal tracts support other potential clinical applications of BRS technology.
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