期刊
EXPERT OPINION ON THERAPEUTIC TARGETS
卷 25, 期 6, 页码 467-477出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14728222.2021.1907343
关键词
Fc effector function; infectious disease; passive immunization; vaccination; SARS-CoV-2
资金
- South African Research Chairs Initiative of the Department of Science and Innovation
- South African Research Chairs Initiative of the National Research Foundation of South Africa
- SA Medical Research Council SHIP program
- Centre for the AIDS Program of Research (CAPRISA)
- Poliomyelitis Research Foundation
- Department of Science and Technology
- National Research Foundation
- H3 Africa grant [U01A136677]
Fc effector functions play a crucial role in disease control and protection against infectious diseases, making them important targets for vaccine design. Strategies to elicit and modulate these functions are essential for optimal prevention against infectious diseases.
Introduction Antibodies mediate pathogen neutralization in addition to several cytotoxic Fc functions through engaging cellular receptors and recruiting effector cells. Fc effector functions have been well described in disease control and protection against infectious diseases including HIV, Ebola, malaria, influenza and tuberculosis, making them attractive targets for vaccine design. Areas Covered We briefly summarize the role of Fc effector functions in disease control and protection in viral, bacterial and parasitic infectious diseases. We review Fc effector function in passive immunization and vaccination, and primarily focus on strategies to elicit and modulate these functions as part of a robust vaccine strategy. Expert Opinion Despite their known correlation with vaccine efficacy for several diseases, only recently have seminal studies addressed how these Fc effector functions can be elicited and modulated in vaccination. However, gaps remain in assay standardization and the precise mechanisms of diverse functional assays. Furthermore, there are inherent difficulties in the translation of findings from animal models to humans, given the difference in sequence, expression and function of Fc receptors and Fc portions of antibodies. However, overall it is clear that vaccine development to elicit Fc effector function is an important goal for optimal prevention against infectious disease.
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