4.5 Article

The D allele of angiotensin-converting enzyme gene is associated with a worse autonomic heart control in community-based older adults

期刊

EXPERIMENTAL GERONTOLOGY
卷 146, 期 -, 页码 -

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2021.111227

关键词

Aging; Heart rate variability; Sympathovagal balance; Gene polymphism; Renin-angiotensin-aldosterone system

资金

  1. Universidade Estadual do Sudoeste da Bahia
  2. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
  3. Fundacao de Amparo a Pesquisa do Estado da Bahia (FAPESB) [SUS 0055/2013]

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The study compared autonomous heart control in older adults with different ACE I/D gene polymorphisms, finding that those with the DD genotype had statistically greater sympathetic modulation but the Bayesian analysis indicated only an anecdotal effect. Sympathetic predominance is recognized as a worrying condition, since it may predispose to cardiovascular risk.
The relationship between the Renin-Angiotensin-Aldosterone System (RAAS) and modulation of the Autonomic Nervous System (ANS) is reported as complex and bidirectional. Thus, the present study aimed to compare autonomous heart control, through symbolic analysis parameters, in the older adults carrying different ACE I/D gene polymorphisms (rs4646994). Two hundred four older adults comprised the study population and were grouped according to the ACE I/D gene polymorphism: II + ID genotype and DD genotype. Successive RR intervals were recorded along 5 min and analyzed with Symbolic Analysis (SA) method. 0 V%, 1 V% and 2 V% patterns were quantified and compared between groups. A linear mixed model analysis was used to determine between-group differences in symbolic analysis parameters (0 V%, 1 V% and 2 V%), taken groups as fixed factor and sex, use of ACE inhibitors and Angiotensin II receptor type I blockers as random factors. The Bayesian analysis was carried out to check the magnitude of the evidence. The results of this study indicate that older adults carrying the DD genotype have statistically greater sympathetic modulation (0 V%) and poor sympathovagal balance (1 V%), but the Bayesian analysis indicate only an anecdotal effect. Sympathetic predominance is recognized a worrying condition, since may predisposes to cardiovascular risk.

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