4.6 Article

Herpes simplex virus 1 proteins can induce skin inflammation in an atopic dermatitis-like mouse model

期刊

EXPERIMENTAL DERMATOLOGY
卷 30, 期 11, 页码 1699-1704

出版社

WILEY
DOI: 10.1111/exd.14327

关键词

atopic dermatitis; eczema herpeticum; herpes simplex virus; mast cells; skin inflammation

资金

  1. Community of Madrid (Regional Ministry of Science, Universities, and Innovation, Madrid, Spain) [2019-T1/BIO-12690]
  2. BONFOR Grant
  3. Strategic Health Action (AES 2020), Carlos III Health Institute, Spanish Ministry of Science and Innovation [PI20/00351]
  4. European Regional Development Fund
  5. German Research Foundation (DFG) [EXC 1023, EXC 2151]

向作者/读者索取更多资源

HSV-1 protein gD can significantly increase T cell and mast cell infiltration in the skin, leading to inflammation. In contrast, VP22 and gB contribute less to skin inflammation.
Herpes simplex virus type 1 (HSV-1) can induce in certain individuals with atopic dermatitis (AD) severe cutaneous infections that can spread throughout the entire body, a condition named as AD complicated by eczema herpeticum (ADEH). It has been recently found that ADEH patients can produce specific IgE against HSV-1 proteins, which may contribute to lower protection against HSV-1. However, little is known about the capacity of these HSV-1 proteins to produce an inflammatory response at the skin level. In this study, using a mouse model of AD-like dermatitis, three HSV-1 proteins (glycoprotein D -gD-, glycoprotein B -gB- and VP22) were applied on tape-stripped back skin mice in three exposures periods. Ovalbumin (OVA) and 0.9% NaCl were used as positive and negative controls, respectively. Skin samples were obtained for analysis of specific cell components of skin infiltration. The results showed that the viral protein gD induced a statistically significant increase in the number of dermal infiltrating CD3+, CD4+ cells and mast cells compared with the negative control group. gD was also able to induce epidermal thickening and epidermal infiltration of T cells closely related to the one produced in mice sensitized with OVA. However, VP22 and gB contributed to a lesser extent to skin inflammation. These results showed that proteins from HSV-1, especially gD, can have per se an important T cell and mast cell-driven inflammatory potential at the skin level.

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