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The Impact of Insulin Resistance on Cardiovascular Control During Exercise in Diabetes

期刊

EXERCISE AND SPORT SCIENCES REVIEWS
卷 49, 期 3, 页码 157-167

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000259

关键词

insulin resistance; hyperglycemia; diabetes; exercise blood pressure; sympathetic nerve activity; exercise pressor reflex; central command

资金

  1. National Institutes of Health [R01-HL-151632, R01-HL-133179, P30DK079328]

向作者/读者索取更多资源

Research suggests that high levels of insulin or blood glucose significantly impact neural regulatory pathways controlling circulation during exercise in diabetic patients.
Patients with diabetes display heightened blood pressure response to exercise, but the underlying mechanism remains to be elucidated. There is no direct evidence that insulin resistance (hyperinsulinemia or hyperglycemia) impacts neural cardiovascular control during exercise. We propose a novel paradigm in which hyperinsulinemia or hyperglycemia significantly influences neural regulatory pathways controlling the circulation during exercise in diabetes.

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