期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 45, 期 -, 页码 108-121出版社
ELSEVIER
DOI: 10.1016/j.euroneuro.2020.11.001
关键词
Mood disorders; Psychotic disorders; Inflammation; Biomarkers; Precision medicine
This article discusses the relationship between immune dysregulation and psychiatric disorders, proposes possible patient subgroups based on clinical dimensions, and explores the potential for personalized treatment.
Diverse lines of research testify a link, presumably causal, between immune dysregulation and the development, course and clinical outcome of psychiatric disorders. However, there is a large heterogeneity among the patients? individual immune profile and this heterogeneity prevents the development of precise diagnostic tools and the identification of therapeutic targets. The aim of this review was to delineate possible subgroups of patients on the basis of clinical dimensions, investigating whether they could lead to particular immune signatures and tailored treatments. We discuss six clinical entry points; genetic liability to immune dysregula-tion, childhood maltreatment, metabolic syndrome, cognitive dysfunction, negative symptoms and treatment resistance. We describe the associated immune signature and outline the effects of anti-inflammatory drugs so far. Finally, we discuss advantages of this approach, challenges and future research directions. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据